To pool or not to pool: That is the question in microbial kinetics

To pool, or not to pool?

Let's start with the most familiar context for pooling data (at least to students in introductory courses in statistics), viz., the pooling of sample variances in a t test of the significance of the difference between two independent sample means. The null hypothesis to be tested is that the means of two populations are equal (the populations from which the respective samples have been randomly...

Commentary To Pool , or Not to Pool ?

IN this issue of Genetics, Futschik and Schlötterer (2010) present one of the first and the most systematic explorations of the relative merits of pooling vs. individual sequencing for several genetics applications. They argue that pooling individuals is often more effective both for SNP discovery and for the estimation of allele frequencies (and thus for population genomic analyses) and as a r...

To Pool or Not To Pool? Revisiting an Old Pattern

We revisit the well-known object-pool design pattern in Java. In the last decade, the pattern has attracted a lot of criticism regarding its validity when used for light-weight objects that are only meant to hold memory rather than any other resources (database connections, sockets etc.) and in fact, common opinion holds that is an “anti-pattern” in such cases. Nevertheless, we show through sev...

coeliac disease: to classify or not to classify – that is the question!

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the student committee of sports medicine research center: to be independent or not to be? that is the question